2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101010
    Methylfurmethide iodide 1197-60-0 98%
    Methylfurmethide is an acetylcholine receptor. Methylfurmethide blocks the uptake of atropine. Methylfurmethide can be used to study the properties of acetylcholine receptors in intestinal smooth muscle .
    Methylfurmethide iodide
  • HY-101039
    AR-M 1000390 209808-01-5 98%
    AR-M 1000390 is an exceptionally selective, potent δ opioid receptor agonist with an EC50 of 7.2±0.9 nM for δ agonist potency.
    AR-M 1000390
  • HY-101049
    CGS 12066 dimaleate 109028-10-6 98%
    CGS 12066 (dimaleate) dimaleate is a selective 5-HT1B receptor agonist with an IC50 of 51 nM.
    CGS 12066 dimaleate
  • HY-101062
    3-AQC 201216-42-4 98%
    3-AQC, a piperazinylquinoxaline derivative, is a potent and competitive 5-HT3 receptor antagonist.
    3-AQC
  • HY-101078
    (±)-Epibatidine 148152-66-3 98%
    (±)-Epibatidine is a nicotinic agonist. (±)-Epibatidine is a neuronal nAChR agonist.
    (±)-Epibatidine
  • HY-101080
    3'-Fluorobenzylspiperone maleate 1135278-61-3 98%
    3'-Fluorobenzylspiperone maleate is a ligand for dopamine D2 receptors with activity in improving behavioral disorders. 3'-Fluorobenzylspiperone maleate showed better inhibitory effects than placebo, especially in reducing behavioral disorders.
    3'-Fluorobenzylspiperone maleate
  • HY-101100
    Anpirtoline hydrochloride 99201-87-3 99.86%
    Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT1B receptor agonist, with Kis of 28 nM (5-HT1B), 150 nM (5-HT1A) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects.
    Anpirtoline hydrochloride
  • HY-101105
    SB-224289 180083-23-2 98%
    SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect.
    SB-224289
  • HY-101139
    Xanthine amine congener 96865-92-8 98%
    Xanthine amine congener is a non-selective adenosine receptor antagonist. Xanthine amine congener induces convulsions in mice.
    Xanthine amine congener
  • HY-101164
    MAP4 157381-42-5 98%
    MAP4 is a selective group III mGluR antagonist in some electrophysiological systems.
    MAP4
  • HY-101181
    THK-5105 1374107-46-6 98%
    THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)  brain homogenates. 18F-THK-5105 has the potential to act as a tau imaging PET probe.
    THK-5105
  • HY-101185
    T808 1320211-61-7 98%
    T808 is a tau-selective Alzheimer’s PET ligand. T808 is a type of imaging agent used in positron emission tomography (PET) scans. It is a radiotracer that is used to help visualize certain areas of the body, such as the brain, in order to diagnose and monitor various medical conditions.
    T808
  • HY-101196
    PG 9 maleate 155649-00-6 98%
    PG 9 maleate is a compound with analgesic and anti-memory loss activity. PG 9 maleate exerts analgesic effects by enhancing central cholinergic transmission. PG 9 maleate protects against memory loss caused by scopolamine or dicyclomine within a specific dose range. The affinity profile of PG 9 maleate indicates significant selectivity among the M4/M1 receptor subtypes, which may be the mechanism for its analgesic and anti-memory loss effects. PG 9 maleate can increase the release of acetylcholine, thereby improving its biological activity.
    PG 9 maleate
  • HY-101199
    N-Benzylnaltrindole hydrochloride 1206487-81-1 98%
    N-Benzylnaltrindole hydrochloride is a potent δ2-selective opioid receptor antagonist. Benzylnaltrindole hydrochloride has a long duration of action in vivo than Naltriben (NTB). N-Benzylnaltrindole hydrochloride iserve as a useful tool in the pharmacologic characterization of δ-opioid receptor function.
    N-Benzylnaltrindole hydrochloride
  • HY-101208
    L694247 137403-12-4 98%
    L694247 is a selective 5-HT1D agonist with the pIC50 values of 10.03, 8.64, 6.42, and 5.66 for 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors , respectively.
    L694247
  • HY-10121B
    Asenapine citrate 1411867-74-7 98%
    Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder.
    Asenapine citrate
  • HY-101220
    RMI-61140 24140-98-5 98%
    RMI-61140 is an orally active neuroleptics. RMI-61140 decreases spontaneous motility and muscle tone in mice. RMI-61140 increases barbit urate-induced sleep and causes eyelid ptosis. RMI-61140 can be used for schizophrenia research.
    RMI-61140
  • HY-101229
    (2R,3S)-Chlorpheg 140924-23-8 98%
    (2R,3R)-Chlorpheg is a week antagonist of L-homocysteic acid (L-HCA) induced depolarization.(2R,3R)-Chlorpheg also is a weak N-methyl-D-aspartate (NMDA) antagonist.
    (2R,3S)-Chlorpheg
  • HY-101233
    ICI 154129 83420-94-4 98%
    ICI 154 129 is a delta-opioid receptor antagonist and can be used for seizure research.
    ICI 154129
  • HY-101241
    MPPG 169209-65-8 98%
    MPPG is a potent and selective L-AP4-sensitive receptor antagonist with an kD value of 9.2 μM, being tested on the neonatal rat spinal cord.
    MPPG
Cat. No. Product Name / Synonyms Application Reactivity